研究業績

2024

原著論文

Murayama T, Otori Y, Kurebayashi N, Yamazawa T, Oyamada H, Sakurai T, Ogawa H. Dual role of the S5 segment in type 1 ryanodine receptor channel gating. Commun Biol 7: 1108, 2024[Link]
Hori A, Inaba H, Hato T, Tanaka K, Sato S, Okamoto M, Horiuchi Y, Paran FJ, Tabe Y, Mori S, Rosales C, Akamatsu W, Murayama T, Kurebayashi N, Sakurai T, Ai T, Miida T. Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease. PLoS One. 19: e0291887, 2024[Link]
Lee KE, Nishi M, Kim J, Murayama T, Dawson Z, Wang X, Zhou X, Tan T, Cai C, Takeshima H, Park KH. MG53's non-physiologic interaction with insulin receptor: lack of effect on insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues. Front Endocrinol. 15, 2024.[Link]
Komai M, Noda Y, Ikeda A, Kaneshiro N, Kamikubo Y, Sakurai T, Uehara T, Takasugi N. Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes. J Lipid Res. 2024;65(3):10051[Link]
Okabe Y, Murakoshi N, Kurebayashi N, Inoue H, Ito Y, Murayama T, Miyoshi C, Funato H, Ishii K, Xu D, Tajiri K, Qin R, Aonuma K, Murakata Y, Song Z, Wakana S, Yokoyama U, Sakurai T, Aonuma K, Ieda M and Yanagisawa M (2024) An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice. Proc Natl Acad Sci U S A 121: e2218204121. [Link]
Ishida R, Zeng X, Kurebayashi N, Murayama T, Mori S and Kagechika H (2024) Discovery and Structure-Activity Relationship of a Ryanodine Receptor 2 Inhibitor. Chem Pharm Bull (Tokyo) 72: 399-407. [Link]

総説・和文・招待講演

Takasugi N, Komai M, Kaneshiro N, Ikeda A, Kamikubo Y, Uehara T. The Pursuit of the "Inside" of the Amyloid Hypothesis-Is C99 a Promising Therapeutic Target for Alzheimer's Disease? Cells. 2023 Jan 31;12(3):454. [Link]
大久保洋平　カルシウムチャネル　Clinical Neuroscience, 41(7): 902-906, 2023

2023

原著論文

Hu J, Venturi E, Sigalas C, Murayama T, Nishi M, Takeshima H, Sitsapesan R. The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2. J Gen Physiol, 155: e202113070, 2023.[Link]
Gao J, Makiyama T, Yamamoto Y, Kobayashi T, Aoki H, Maurissen TL, Wuriyanghai Y, Kashiwa A, Imamura T, Aizawa T, Huang H, Kohjitani H, Nishikawa M, Chonabayashi K, Fukuyama M, Manabe H, Nakau K, Wada T, Kato K, Toyoda F, Yoshida Y, Makita N, Woltjen K, Ohno S, Kurebayashi N, Murayama T, Sakurai T, Horie M, Kimura T. Novel calmodulin variant p.E46K associated with severe catecholaminergic polymorphic ventricular tachycardia produces robust arrhythmogenicity in human induced pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol, 16: e011387, 2023[Link]
Kamikubo Y, Jin H, Zhou Y, Niisato K, Hashimoto Y, Takasugi N, Sakurai T. Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage. Front. Mol. Neurosci.15:1068990, 2023[Link]
Okamoto K, Kamikubo Y, Yamauchi K, Okamoto S, Takahashi M, Ishida Y, Koike M, Ikegaya Y, Sakurai T, Hioki H. Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle. Sci Rep.6;13(1):323. 2023 [Link]
Ishida R, Kurebayashi N, Iinuma H, Zeng X, Mori S, Kodama M, Murayama T, Masuno H, Takeda F, Kawahata M, Tanatani A, Miura A, Nishio H, Sakurai T and Kagechika H (2023) A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. Eur J Med Chem 262: 115910. [Link]
Takenaka M, Kodama M, Murayama T, Ishigami-Yuasa M, Mori S, Ishida R, Suzuki J, Kanemaru K, Sugihara M, Iino M, Miura A, Nishio H, Morimoto S, Kagechika H, Sakurai T and Kurebayashi N (2023) Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring. Mol Pharmacol 104: 275-286 [Link]

総説・和文・招待講演

Matsukawa H, Murayama T. Development of ryanodine receptor (RyR) inhibitors for skeletal muscle and heart diseases. Juntendo Med J, 69: 180-187, 2023[Link]
Murayama T, Kurebayashi N, Ishida R, Kagechika H. Drug development for the treatment of RyR1-related skeletal muscle diseases. Curr Opin Pharmacol, 69: 102356, 2023[Link]
小林琢也, 上窪裕二, 櫻井隆; アドレナリン受容体と薬物の結合の構造学的基盤. Clinical Neuroscience, 41(1): 7-9, 2023

2022

原著論文

Kamikubo Y, Yamana T, Inoue Y, Sakurai T. Multifaceted analysis of nanotoxicity using primary cultured neurons. Nano Express, 3(3): 035003, 2022[Link]
Sasaki R, Kurebayashi N, Eguchi H, Horimoto Y, Shiga T, Miyazaki M, Kashiyama T, Akamatsu W, Saito M. Involvement of kallikrein-PAR2-proinflammatory pathway in severe trastuzumab-induced cardiotoxicity. Cancer Sci, 113:3449-3462, 2022 DOI: 10.1111/cas.15508[Link]
Murayama T, Kurebayashi N, Numaga-Tomita T, Kobayashi T, Okazaki S, Yamashiro K, Nakada T, Mori S, Ishida R, Kagechika H, Yamada M, Sakurai T. A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery. J Gen Physiol, 154: e202213230, 2022[Link]
Ishida R, Mori S, Murayama T, Nakamichi A, Chai X, Kurebayashi N, Iinuma H, Kagechika H. Development of a water-soluble ryanodine receptor 1 inhibitor. Bioorg Med Chem, 74: 117027, 2022[Link]
Tsuboi Y, Oyama K, Kobirumaki-Shimozawa F, Murayama T, Kurebayashi N, Tachibana T, Manome Y, Kikuchi E, Noguchi S, Inoue T, Inoue YU, Nishino I, Mori S, Ishida R, Kagechika H, Suzuki M, Fukuda N, and Yamazawa T. Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes. J Gen Physiol, 154: e202213136, 2022[Link]
Oyama K, Zeeb V, Yamazawa T, Kurebayashi N, Kobirumaki-Shimozawa F, Murayama T, Oyamada H, Noguchi S, Inoue T, Inoue YU, Nishino I, Harada Y, Fukuda N, Ishiwata S, Suzuki M. Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating. Proc Natl Acad Sci U S A 119, e2201286119, 2022[Link]
Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease. iScience. 2022;25(3):103869. [Link]
Komiya E, Tominaga M, Hatano R, Kamikubo Y, Toyama S, Sakairi H, Honda K, Itoh T, Kamata Y, Tsurumachi M, Kishi R, Ohnuma K, Sakurai T, Morimoto C, Takamori K. Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV. J Allergy Clin Immunol. 2022;149(3):1085-1096. [Link]
Kobayashi T, Tsutsumi A, Kurebayashi N, Saito K, Kodama M, Sakurai T, Kikkawa M, Murayama T, Ogawa H. Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Nat Commun 13, 2821, 2022 [Link]
Kurebayashi, N., T. Murayama, R. Ota, J. Suzuki, K. Kanemaru, T. Kobayashi, S. Ohno, M. Horie, M. Iino, F. Yamashita, and T. Sakurai. 2022. Cytosolic Ca²⁺-dependent Ca²⁺ release activity primarily determines the ER Ca²⁺ level in cells expressing the CPVT-linked mutant RYR2. J Gen Physiol. DOI: 154. 10.1085/jgp.202112869[Link]
Inazumi, H., K. Kuwahara, Y. Nakagawa, Y. Kuwabara, T. Numaga-Tomita, T. Kashihara, T. Nakada, N. Kurebayashi, M. Oya, M. Nonaka, M. Sugihara, H. Kinoshita, K. Moriuchi, H. Yanagisawa, T. Nishikimi, H. Motoki, M. Yamada, S. Morimoto, K. Otsu, R.M. Mortensen, K. Nakao, and T. Kimura. 2022. NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca²⁺ Homeostasis. DOI: Circ Res. 130:234-248. 10.1161/CIRCRESAHA.121.318898[Link]
Hirose, S., T. Murayama, N. Tetsuo, M. Hoshiai, H. Kise, M. Yoshinaga, H. Aoki, M. Fukuyama, Y. Wuriyanghai, Y. Wada, K. Kato, T. Makiyama, T. Kimura, T. Sakurai, M. Horie, N. Kurebayashi, and S. Ohno. 2022. Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome. Europace. 24:497-510. DOI: 10.1093/europace/euab250[Link]

総説・和文・招待講演

上窪裕二, 小林琢也, 櫻井隆; アドレナリン受容体の種類と機能. Clinical Neuroscience 40(12): 1502-1504, 2022
Okubo Y. Investigation of Brain Functions with Fluorescence Imaging Techniques. Juntendo Medical Journal: 68: 157-162, 2022[Link]

2021

原著論文

Kuroda Y, Nonaka M, Kamikubo Y, Ogawa H, Murayama T, Kurebayashi N, Sakairi H, Miyano K, Komatsu A, Dodo T, Nakano-Ito K, Yamaguchi K, Sakurai T, Iseki M, Hayashida M, Uezono Y. Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors. Biomed Pharmacother; 141: 111800, 2021[Link]
Yamazawa T, Kobayashi T, Kurebayashi N, Konishi M, Noguchi S, Inoue T, Inoue YU, Nishino I, Mori S, Iinuma H, Manaka M, Kagechika H, Uryash A, Adams J, Lopez JR, Liu X, Diggle C, Allen PD, Kakizawa S, Ikeda K, Lin B, Ikemi Y, Nunomura K, Nakagawa S, Sakurai T, Murayama T. A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke. Nat Commun, 12: 4293, 2021[Link]
Hu Y, Iyer KA, Nayak AR, Kurebayashi N, Murayama T, Samso M. Purification of recombinant wild type and mutant ryanodine receptors expressed in HEK293 cells. Bio-protocol, 11: e4112, 2021[Link]
Sakata K, Matsuyama S, Kurebayashi N, Hayamizu K, Murayama T, Nakamura K, Kitamura K, Morimoto S, Takeya R. Differential effects of the formin inhibitor SMIFH2 on contractility and Ca²⁺ handling in frog and mouse cardiomyocytes. Genes Cells, 26: 583?595, 2021[Link]
Itoh H, Murayama T, Kurebayashi N, Ohno S, Kobayashi T, Fujii Y, Watanabe M, Ogawa H, Anzai T, Horie M. Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation. J Electroncardiol, 69: 111-118, 2021[Link]
Inoue H, Murayama T, Kobayashi T, Konishi M, and Yokoyama U. The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity. J Gen Physiol (2021) 153 (6): e202012708. [Link]

総説・和文・招待講演

Kobayashi T, Kurebayashi N, Murayama T. The ryanodine receptor as a sensor for intracellular environments in muscles. Int J Mol Sci, 22: 10795, 2021[Link]
大久保洋平　神経細胞における細胞内カルシウムストアの機能解析　ブレインサイエンス・レビュー2021　廣川信隆、坂東武彦／編　アドスリー　111-128, 2021
Kamikubo Y, Wakisaka K, Imai Y, Sakurai T. Midbrain Slice Culture as an Ex Vivo Analysis Platform for Parkinson's Disease. Methods Mol Biol; 2322: 111-117, 2021[Link]
上窪裕二, 田端俊英, 坂入伯駿, 櫻井隆. 異種G蛋白質共役型受容体相互作用による代謝型グルタミン酸受容体の制御. 脳神経内科: 94(4): 468-475, 2021[Link]

2020

原著論文

Yamazaki Y, Nagai J, Akinaga S, Koga Y, Hasegawa M, Takahashi M, Yamashita N, Kolattukudy P, Goshima Y, Ohshima T.: Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4. Brain Res. doi: 10.1016/j.brainres.2020.146762, 2020 [Link]
Sakairi H, Kamikubo Y, Abe M, Ikeda K, Ichiki A, Tabata T, Kano M, Sakurai T. G Protein-Coupled Glutamate and GABA Receptors Form Complexes and Mutually Modulate Their Signals. ACS Chem Neurosci. 11: 567-578, 2020 [PubMed]
Takahashi S, Hanaoka K, Okubo Y, Echizen H, Ikeno T, Komatsu T, Ueno T, Hirose K, Iino M, Nagano T, Urano Y. Rational design of a near-infrared fluorescence probe for Ca²⁺ based on phosphorus-substituted rhodamines utilizing photoinduced electron transfer. Chem Asian J, 15: 524-530, 2020.[Link]
Okubo Y, Iino M, Hirose K. Store-operated Ca²⁺ entry-dependent Ca²⁺ refilling in the endoplasmic reticulum in astrocytes. Biochem Biophys Res Commun, 522: 1003-1008, 2020.[Link]
Ma R, Haji-Ghassemi O, Ma D, Jiang H, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z. Structural basis for diamide modulation of ryanodine receptor. Nat Chem Biol. 2020.[Link]
Iyer KA, Hu Y, Nayak AR, Kurebayashi N, Murayama T, Samso M. Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM. Sci Adv. 6: eabb2964, 2020.[Link]
Saito K, Murayama T, Hata T, Kobayashi T, Shibata K, Kazuno S, Fujimura T, Sakurai T, Toyoshima YY. Conformational diversity of dynactin sidearm and domain organization of its subunit p150. Mol Biol Cell. 31:1218-1231, 2020.[Link]
Ogawa H, Kurebayashi N, Yamazawa T, Murayama T. Regulatory mechanisms of ryanodine receptor/Ca²⁺ release channel revealed by recent advancements in structural studies, J Muscle Res Cell Motil, 2020.[Link]
Zhou X, Park KH, Yamazaki D, Lin PH, Nishi M, Ma Z, Qiu L, Murayama T, Zou X, Takeshima H, Zhou J, Ma J. TRIC-A channel maintains store calcium handling by interacting with type 2 ryanodine receptor in cardiac muscle. Circ Res, 126: 417-435, 2020.[Link]
Nozaki Y, Kato Y, Uike K, Yamamura K, Kikuchi M, Yasuda M, Ohno S, Horie M, Murayama T, Kurebayashi N, Horigome H. Co-Phenotype of Left Ventricular Non-Compaction Cardiomyopathy and Atypical Catecholaminergic Polymorphic Ventricular Tachycardia in Association With R169Q, a Ryanodine Receptor Type 2 Missense Mutation. Circ J, 84: 226-234, 2020.[Link]
Yamazawa T, Ogawa H, Murayama T, Yamaguchi M, Oyamada H, Suzuki J, Kurebayashi N, Kanemaru K, Oguchi K, Sakurai T, Iino M. Insights into channel modulation mechanism of RYR1 mutants using Ca²⁺ imaging and molecular dynamics. J Gen Physiol (2020) 152 (1): e201812235.[Link]

総説・和文・招待講演

Okubo Y. Astrocytic Ca²⁺ signaling mediated by the endoplasmic reticulum in health and disease. J Pharmacol Sci, 144: 83-88, 2020.[Link]
Okubo Y, Iino M. Visualization of astrocytic intracellular Ca²⁺ mobilization. J Physiol, 598: 1671-1681, 2020.[Link]
呉林なごみ、村山尚、　2型リアノジン受容体の活性異常による不整脈疾患とその治療戦略日本薬理学雑誌155:225-229, 2020 doi: 10.1254/fpj.20017.[Link]
上窪裕二, 櫻井隆. 生体内の情報伝達の基礎. エース薬理学(南山堂): 3-10, 2020

2019

原著論文

Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.: Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A. Neurosci Res, 139:63-68, 2019 [Link]
Sou YS, Kakuta S, Kamikubo Y, Niisato K, Sakurai T, Parajuli LK, Tanida I, Saito H, Suzuki N, Sakimura K, Maeda Y, Kinoshita T, Uchiyama Y, Koike M. Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice. eNeuro, 6: e0427-18, 2019
Kamikubo Y, Yamana T, Hashimoto Y, Sakurai T. Induction of Oxidative Stress and Cell Death in Neural Cells by Silica Nanoparticles. ACS Chem Neurosci: 10: 304-312, 2019[Link]
Uzu, M., M. Nonaka, K. Miyano, H. Sato, N. Kurebayashi, K. Yanagihara, T. Sakurai, A. Hisaka, and Y. Uezono. A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain. J Pharmacol Sci. 140:109-112, 2019.[Link]
Mori S, Iinuma H, Manaka N, Ishigami-Yuasa M, Murayama T, Nishijima Y, Sakurai A, Arai R, Kurebayashi N, Sakurai T, and Kagechika H. Structural development of a type-1 ryanodine receptor (RyR1) Ca²⁺-release channel inhibitor guided by endoplasmic reticulum Ca²⁺ assay. Eur J Med Chem 179: 837-848, 2019. [Link]
Saeki T, Kimura T, Hashidume K, Murayama T, Yamamura H, Ohya S, Suzuki Y, Nakayama S, Imaizumi Y: Conversion of Ca²⁺ oscillation into propagative electrical signals by Ca²⁺-activated ion channels and connexin as a reconstituted Ca²⁺ clock model for the pacemaker activity. Biochem Biophys Res Commun, 510: 242-247, 2019.[Link]
Narita K, Suzuki N, Himi N, Murayama T, Nakagawa T, Okabe N, Nakamura-Maruyama E, Hayashi N, Sakamoto I, Miyamoto O, Kuba K. Effects of intravesicular loading of a Ca²⁺ chelator and depolymerization of actin fibers on neurotransmitter release in frog motor nerve terminals. Eur J Neurosci, 50: 1700-1711, 2019.[Link]
Eshima H, Tamura Y, Kakehi S, Nakamura K, Kurebayashi N, Murayama T, Kakigi R, Sakurai T, Kawamori R, Watada H. Dysfunction of muscle contraction with impaired intracellular Ca²⁺ handling in skeletal muscle and the effect of exercise training in male db/db mice. J Appl Physiol (1985), 126(1): 170-182, 2019.[Link]

総説・和文・招待講演

Murayama T, Kurebayashi N. Assays for modulators of ryanodine receptor (RyR)/Ca²⁺ release channel activity for drug discovery for skeletal muscle and heart diseases. Curr Protoc Pharmacol, 87: e71, 2019.[Link]
Yamashita N. Retrograde signaling via axonal transport through signaling endosomes. JPharmacol Sci, 141(2):91-96, 2019 [Link]
Kamikubo Y and Sakurai T.: Co-immunoprecipitation Analysis of GPCR Complexes in the Central Nervous System. Neuromethods 114. Co-Immunoprecipitation Methods for Brain Tissue. 2019 [Link]
山下直也　最近の話題：神経成長因子による逆行性シグナル伝達研究の新展開日本薬理学会誌　2019年 Vol. 154, No2, 84頁 [Link]
山下直也　最近の話題：アミロイドβ前駆タンパク質による神経伝達物質受容体の局在・機能制御　日本薬理学会誌　2019年 Vol. 154, No5, 288頁[Link]
坂入伯駿、上窪裕二、田端俊英; GABAB受容体の薬理と臨床応用. Clinical Neuroscience 37: 760-761, 2019
田端俊英、上窪裕二、坂入伯駿; GABAB受容体の生理的機能. Clinical Neuroscience 37: 630-631, 2019
上窪裕二、坂入伯駿、田端俊英; GABAB受容体の種類と構造. Clinical Neuroscience 37: 504-505, 2019

2018

原著論文

Nakamura H, Takahashi-Jitsuki A, Makihara H, Asano T, Kimura Y, Nakabayashi J, Yamashita N, Kawamoto Y, Nakamura F, Ohshima T, Hirano H, Tanaka F, Goshima Y.: Proteome and behavioral alterations in phosphorylation-deficient mutant Collapsin Response Mediator Protein2 knock-in mice. Neurochem Int, 119:207-217, 2018 [Link]
Murayama, T, Ogawa H, Kurebayashi N, Ohno S, Horie M, Sakurai T: A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca²⁺ sensitivity. Commun Biol, 1: 98, 2018. [PubMed]
Kaneshiro N, Imaoka R, Komai M, Kashiyama T, Sakurai T, Uehara T, Takasugi N.: Functional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells. BBRC, 2018, in press. [PubMed]
Murayama, T, Kurebayashi N, Ikegami-Yuasa M, Mori S, Suzuki Y, Akima R, Ogawa H, Suzuki J, Kanemaru K, Oyamada H, Kiuchi Y, Iino M, Kagechika H, Sakurai T: Efficient high-throughput screening by ER Ca²⁺ measurement to identify inhibitors of ryanodine receptor Ca²⁺-release channels. Mol Pharmacol, 94: 722-730, 2018. [PubMed]
Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T.: TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes. PLoS ONE 13(8): e0200988, 2018. [PubMed]

2017

原著論文

Yamashita N, Joshi R, Zhang S, Zhang ZY, Kuruvilla R. "Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors." Dev Cell, Volume 42, Issue 6, 25 September 2017, Pages 626-639 [PubMed]
Masukawa D, Koga M, Sezaki A, Nakao Y, Kamikubo Y, Hashimoto T, Okuyama-Oki Y, Aladeokin AC, Nakamura F, Yokoyama U, Wakui H, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, Goshima Y: L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor. JCI Insight,2:e90903, 2017 [PubMed]
Kamikubo Y, Takasugi N, Niisato K, Hashimoto Y, Sakurai T: Consecutive analysis of BACE1 function on developing and developed neuronal cells. J Alzheimers Dis. 56:641-653, 2017 [PubMed]
Hashimoto K, Kodama A, Honda T, Hanashima A, Ujihara Y, Murayama T, Nishimatsu SI, Mohri S: Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice. Sci Rep, 7: 4486, 2017 [PubMed]
Uehara A, Murayama T, Yasukochi M, Fill M, Horie M, Okamoto T, Matsuura Y, Uehara K, Fujimoto T, Sakurai T, Kurebayashi N: Extensive Ca²⁺ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca²⁺ hypersensitivity. J Gen Physiol, 149:199-218, 2017 [PubMed]
Fujii Y, Itoh H, Ohno S, Murayama T, Kurebayashi N, Aoki H, Blancard M, Nakagawa Y, Yamamoto S, Matsui Y, Ichikawa M, Sonoda K, Ozawa T, Ohkubo K, Watanabe I, Guicheney P, Horie M: A type 2 ryanodine receptor variant associated with reduced Ca²⁺ release and short-coupled torsade de pointe ventricular arrhythmia. Heart Rhythm, 14: 98-107, 2017 [PubMed]

総説・和文・招待講演

上窪裕二, 田端俊英; アデノシン受容体をターゲットとした臨床応用と最新研究. Clinical Neuroscience, 35: 128-129, 2017
田端俊英, 上窪裕二; アデノシン受容体の神経系における機能と役割. Clinical Neuroscience, 56: 641-653, 2017

2016

原著論文

Nonobe Y, Yokoyama T, Kamikubo Y, Yoshida S, Hisajima N, Shinohara H, Shiraishi Y, Sakurai T, Tabata T: Application of surface plasmon resonance imaging to monitoring G protein-coupled receptor signaling and its modulation in a heterologous expression system. BMC Biotechnol, 16:36, 2016 [PubMed]
Murayama T, Kurebayashi N, Ogawa H, Yamazawa T, Oyamada H, Suzuki J, Kanemaru K, Oguchi K, Iino M, Sakurai T: Genotype-phenotype correlations of malignant hyperthermia and central core disease mutations in the central region of the RYR1 channel. Hum Mutat, 37: 1231-1241, 2016 [PubMed]
Cabra V, Murayama T, Samso M: Ultrastructural analysis of self-associated RyR2s. Biophys J 110: 2651-2662, 2016 [PubMed]
Mikami Y, Kanemaru K, Okubo Y, Nakaune T, Suzuki J, Shibata K, Sugiyama H, Koyama R, Murayama T, Ito A, Yamazawa T, Ikegaya Y, Sakurai T, Saito N, Kakizawa S, Iino M. Nitric oxide-induced activation of the type 1 ryanodine receptor is critical for epileptic seizure-induced neuronal cell death. EBioMedicine 11: 253-261, 2016 [PubMed]
Sato T, Watanabe M, Tsuzuki T, Takano S, Murayama T, Sakurai T, Kameda T, Fukuda H, Arisawa M, Shuto S: Design, synthesis, and identification of 4''alpha-azidoethyl-cyclic ADP-carbocyclic-ribose as a highly potent analogue of cyclic ADP-ribose, a Ca²⁺-mobilizing second messenger. J Med Chem, 59: 7282-7286, 2016 [PubMed]
Fukunaga I, Fujimoto A, Hatakeyama K, Aoki T, Nishikawa A, Noda T, Minowa O, Kurebayashi N, Ikeda K, Kamiya K. In Vitro Models of GJB2-Related Hearing Loss Recapitulate Ca²⁺ Transients via a Gap Junction Characteristic of Developing Cochlea. Stem Cell Reports. 2016 [PubMed]

総説・和文・招待講演

上窪裕二、田端俊英; グループII型およびIII型代謝型グルタミン酸受容体の生理的および薬理的作用. Clinical Neuroscience, 34; 256-257, 2016
上窪裕二、田端俊英; グループI型代謝型グルタミン酸受容体の生理的および薬理的作用. Clinical Neuroscience, 34; 136-137, 2016
上窪裕二、田端俊英; 代謝型グルタミン酸受容体の構造と種類. Clinical Neuroscience, 34; 8-9, 2016
田端俊英, 上窪裕二; アデノシン受容体の種類とあらまし. Clinical Neuroscience, 34; 1288-1289, 2016

2015

原著論文

Murayama T, Kurebayashi N, Yamazawa T, Oyamada H, Suzuki J, Kanemaru K, Oguchi K, Iino M, Sakurai T: Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region. PLoS One, 10: e0130606, 2015 [PubMed]
Nonaka M, Morimoto S, Murayama T, Kurebayashi N, Li L, Wang YY, Arioka M, Yoshihara T, Takahashi-Yanaga F, Sasaguri T: Stage-dependent benefits and risks of pimobendan in mice with genetic dilated cardiomyopathy and progressive heart failure. Br J Pharmacol, 172: 2369-2382,2015 [PubMed]
Kurosawa M, Matsumoto G, Sumikura H, Hatsuta H, Murayama S, Sakurai T, Shimogori T, Hattori N, Nukina N: Serine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases. Neurosci Res, Epub ahead of print [PubMed]
Kurosawa M, Matsumoto G, Kino Y, Okuno M, Kurosawa-Yamada M, Washizu C, Taniguchi H, Nakaso K, Yanagawa T, Warabi E, Shimogori T, Sakurai T, Hattori N, Nukina N: Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington’s model mice. Hum Mol Genet, 24(4): 1092-1105, 2015 [PubMed]
Hashimoto M, Nara T, Enomoto M, Kurebayashi N, Yoshida M, Sakurai T, Mita T and Mikoshiba K. "A dominant negative form of inositol 1,4,5-trisphosphate receptor induces metacyclogenesis and increases mitochondrial density in Trypanosoma cruzi." Biochem Biophys Res Commun 466: 475-480, 2015. [PubMed]
Kamikubo Y, Tabata T, Sakairi H, Hashimoto Y, Sakurai T; Complex formation and functional interaction between adenosine A1 receptor and type-1 metabotropic glutamate receptor. J Pharmacol Sci, 128: 125-30, 2015 [PubMed]
Inoue Y, Kamikubo Y, Ezure H, Ito J, Kato Y, Moriyama H, Otsuka N: Presynaptic protein Synaptotagmin1 regulates the neuronal polarity and axon differentiation in cultured hippocampal neurons. BMC Neurosci, 16:92, 2015 [PubMed]

2014

原著論文

Odagiri F, Inoue H, Sugihara M, Suzuki T, Murayama T, Shioya T, Konishi M, Nakazato Y, Daida H, Sakurai T, Morimoto S, Kurebayashi N; Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice. PLoS One, 9, e101838, 2014[PubMed]
Murayama T, Kobayashi T: Purification of Recombinant Proteins with a Multifunctional GFP Tag. Methods Mol Biol, 1177: 151-161, 2014[PubMed]
Inoue H, Murayama T, Tashiro M, Sakurai T, Konishi M: Mg²⁺- and ATP-dependent inhibition of transient receptor potential melastatin 7 by oxidative stress. Free Radic Biol Med, 72: 257-266, 2014[PubMed]
Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Karasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K; Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest, 124, 1598-1607, 2014 [PubMed]

総説・和文・招待講演

呉林なごみ; キーワード解説　カルシウム・膜電位イメージング. 日本薬理学雑誌, 143, 45-46, 2014 [J-STAGE]
上窪裕二; Gタンパク質共役型受容体問の相互作用によるシナプス伝達の制御, 生産と技術, 66: 36-38, 2014
上窪裕二, 田端俊英; GPCRヘテロ複合体形成による神経伝達の制御, Clinical Neuroscience, 32: 8-9, 2014

2013

原著論文

Kamikubo Y, Shimomura T, Fujita Y, Tabata T, Kashiyama T, Sakurai T, Fukurotani K, Kano M: Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellum. J Neurosci, 33: 18661-71, 2013 [PubMed]
O-Uchi J, Jhun BS, Hurst S, Bisetto S, Gross P, Chen M, Kettlewell S, Park J, Oyamada H, Smith GL, Murayama T, Sheu SS: Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca²⁺-induced ATP production in cardiac H9c2 myoblasts. Am J Physiol Heart Circ Physiol, in press [PubMed]
Shoji K, Murayama T, Mimura I, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M: Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma. Am J Pathol, 182: 2191-2203, 2013 [PubMed]
Takatsu H, Katoh Y, Ueda T, Waguri S, Murayama T, Takahashi S, Shin HW, Nakayama K: Mitosis-Coupled, Microtubule-Dependent Clustering of Endosomal Vesicles around Centrosomes. Cell Struct Funct, 38: 31-41, 2013 [PubMed]
Tsuzuki T, Sakaguchi N, Kudoh T, Takano S, Uehara M, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Potter BV, Fukuda H, Arisawa M, Shuto S: Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger. Angew Chem, 52: 6633-6637, 2013 [PubMed]
Sugihara M, Odagiri F, Suzuki T, Murayama T, Nakazato Y, Unuma K, Yoshida K, Daida H, Sakurai T, Morimoto S, Kurebayashi N; Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model. PLoS One, 2013; 8:e55514. [link]
Hashimoto M, Enomoto M, Morales J, Kurebayashi N, Sakurai T, Hashimoto T, Nara T, Mikoshiba K; Inositol 1,4,5-trisphosphate receptor regulates replication, differentiation, infectivity and virulence of the parasitic protist Trypanosoma cruzi. Mol Microbiol, 87, 1133-1150, 2013 [PubMed]

総説・和文・招待講演

上窪裕二, 田端俊英; GPCRの複合体形成, Clinical Neuroscience, 31: 1118-1119, 2013

2012

原著論文

Suzuki T, Shioya T, Murayama T, Sugihara M, Odagiri F, Nakazato Y, Nishizawa H, Chugun A, Sakurai T, Daida H, Morimoto S, Kurebayashi N: Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy. PLoS One. 2012;7:e35353 [PubMed]
Kakizawa S, Yamazawa T, Chen Y, Ito A, Murayama T, Oyamada H, Kurebayashi N, Sato O, Watanabe M, Mori N, Oguchi K, Sakurai T, Takeshima H, Saito N, Iino M: Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function. EMBO J, 31: 417-428, 2012 [PubMed]
Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai T, Kohsaka S, Chiba H, Hattori N, Yamada Y, Arikawa-Hirasawa E: Laminin alpha1 is essential for mouse cerebellar development. Matrix Biol, 31: 17-28, 2012 [PubMed]

総説・和文・招待講演

呉林なごみ, 村山　尚：筋小胞体のCa²⁺放出機構の最近の進歩. 生体の科学. 2012; 63: 374-375.
上窪裕二, 田端俊英; GPCRの複合体形成, Clinical Neuroscience, 31: 1118-1119, 2013

著書

呉林なごみ：　心筋Ca²⁺ transientと不整脈発生. 不整脈学 (井上　博、村川裕二　編), 南江堂, 2012; pp153-156.

2011

原著論文

Suzuki N, Hasegawa-Moriyama M, Takahashi Y, Kamikubo Y, Sakurai T, Inada E: Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation. Anesthesia & Analgesia, 113: 941-946, 2011. [PubMed]
Takahashi Y, Hasegawa-Moriyama M, Sakurai T, Inada E: Macrophage-mediated effects of PPAR-gamma agonist rosiglitazone attenuates tactile allodynia in the early phase of neuropathic pain development. Anesthesia & Analgesia, 113: 398-404, 2011 [PubMed]
Aita Y, Kurebayashi N, Hirose S, Maturana AD; Protein kinase D regulates the human cardiac L-type voltage-gated calcium channel through serine 1884. FEBS Lett, 585: 3903-3906, 2011 [PubMed]
Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, et al; Decrease in the density of t-tubular L-type Ca²⁺ channel currents in failing ventricular myocytes. Am J Physiol Heart Circ Physiol, 300:H978-988, 2011 [PubMed]
Kitai T, Watanabe Y, Toyoshima YY, Kobayashi T, Murayama T, Sakaue H, Suzuki H, Takahagi T: Simple method of synthesizing nickel-nitrilotriacetic acid gold nanoparticles with a narrow size distribution for protein labeling. Jpn J App Phys, 50: 095002, 2011.[Link]
Murayama T, Kurebayashi N, Oba T, Oyamada H, Oguchi K, Sakurai T, Ogawa Y: Role of amino-terminal half of the S4-S5 linker in the RyR1 channel gating. J. Biol. Chem., 286: 35571-35577, 2011 [PubMed]
Ichikawa M, Watanabe Y, Murayama T, Toyoshima YY: Recombinant human cytoplasmic dynein heavy chain 1 and 2: Observation of dynein-2 motor activity in vitro. FEBS Lett, 585:2419-2423, 2011 [PubMed]

総説・和文・招待講演

Murayama T, Kurebayashi N: Two ryanodine receptor isoforms in nonmammalian vertebrate skeletal muscle: Possible roles in excitation-contraction coupling and other processes. Prog Biophys Mol Biol, 105:134-144, 2011 [PubMed]

2010

原著論文

Sakamoto Y, Ishijima M, Kaneko H, Kurebayashi N, Ichikawa N, Futami I,Kurosawa H, Arikawa-Hirasawa E. Distinct mechanosensitive Ca²⁺ influxmechanisms in human primary synovial fibroblasts. J Orthop Res.2010 28:859-864 [PubMed]
Kashiyama T, Murayama T, Suzuki E, Allen PD, Ogawa Y: Frog α- and β-ryanodine receptors provide distinct intracellular Ca²⁺ signals in a myogenic cell line. PLoS ONE, 5: e11526, 2010 [PubMed]

総説・和文・招待講演

呉林なごみ, 村山尚. リアノジン受容体. 生体の科学, 61:444-445, 2010
呉林なごみ. 心筋組織の細胞内Ca²⁺および膜電位イメージングによる不整脈発生機構の解析. 解剖学会第115回総会　みちのくシンポジウムI　先端イメージング技術で観る生命の構造と機能の未知領域, 2010年3月
櫻井　隆、樫山　拓、貫名　信行 : マイクロドメインスイッチング：アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシン１　生体の科学,　2010: 61(3) 252-256

2009

原著論文

Tateno M, Kato S, Sakurai T, Nukina N, Takahashi R, Araki T: Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3. Hum Mol Genet, 18: 942-955, 2009
Kobayashi T, Murayama T: Cell cycle-dependent microtubule-based dynamic transport of cytoplasmic dynein in mammalian cells. PLoS ONE 4: e7827, 2009 [Link]
Nishizawa H, Suzuki T, Shioya T, Nakazato Y, Daida H, Kurebayashi N: Causes of abnormal Ca²⁺ transients in Guinea pig pathophysiological ventricular muscle revealed by Ca²⁺ and action potential imaging at cellular level. PLoS ONE 4(9): e7069. [Link]
Kitamura N, Araya R (equally contribute), Kudoh M, Kishida H, Kimura T, Murayama M, Takashima A, Sakamaki Y, Hashikawa T, Ito S, Ohtsuki S, Terasaki T, Wess J. & Yamada M: Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency. PLoS ONE. 4(4) e5159 (2009).

総説・和文・招待講演

Takashi Murayama: Ryanodine receptor isoforms in excitation-contraction coupling in skeletal muscle. 36th Congress of the International Union of Physiological Sciences. Kyoto, 29 July, 2009.

2008

原著論文

Kobayashi T, Morone N, Kashiyama T, Oyamada H, Kurebayashi N, Murayama T: Engineering a novel multifunctional green fluorescent protein tag for a wide variety of protein research. PLoS ONE 3: e3822, 2008 [PubMed]
Shimizu H, Tosaki A, Kaneko K, Hisano T, Sakurai T, Nukina N: Crystal structure of an active form of BACE1: an enzyme responsible for amyloid beta protein production. Mol Cell Biol, 28: 3663-3671, 2008
Sakurai T, Kaneko K, Okuno M, Wada K, Kashiyama T, Shimizu H, Akagi T, Hashikawa T, Nukina N: Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. J Cell Biol, 183: 339-352, 2008
Kurebayashi N, Nishizawa H, Nakazato Y, Kurihara H, Matsushita S, Daida H, Ogawa Y. Aberrant Cell-to-Cell Coupling in Ca²⁺-Overloaded Guinea Pig Ventricular Muscles.　Am J Physiol Cell Physiol. 294: C1419-29, 2008 [PubMed]
Oba T, Maeno Y, Nagao M, Sakuma N, Murayama T: Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca²⁺ release from sarcoplasmic reticulum. Am J Physiol Heart Circ Physiol 294: H121-133, 2008 [PubMed]
Sakaguchi N, Kudoh T, Tsuzuki T, Murayama T, Sakurai T, Matsuda A, Arisawa M, Shuto S: Synthesis of 5''-branched derivatives of cyclic ADP-carbocyclic-ribose, a potent Ca²⁺-mobilizing agent: The first antagonists modified at the N1-ribose moiety. Bioorg Med Chem Lett 18: 3814-3818, 2008 [PubMed]
Meyerkord CL, Takahashi Y, Araya R, Takada N, Weiss RS, Wang HG. Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.Oncogene　27 (2008) 7248-7259
Araya R, Kudo M, Kawano M, Ishii K, Hashikawa T, Iwasato T, Itohara S, Terasaki T, Oohira A, Mishina Y, Yamada M. BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier, Mol Cell Neurosci.38 (2008) 417-30

2007

原著論文

Miyazaki H, Oyama F, Wong HK, Kaneko K, Sakurai T, Tamaoka A and Nukina N: BACE1 modulates filopodia-like protrusions induced by sodium channel beta4 subunit. Biochem Biophys Res Commun 361: 43-48, 2007 [PubMed]
Chugun A, Sato O, Takeshima H and Ogawa Y: Mg²⁺ activates the ryanodine receptor type 2 (RyR2) at intermediate Ca²⁺ concentrations. Am J Physiol Cell Physiol 292: C535-544, 2007 [PubMed]
Rossi D, Murayama T, Manini I, Franci D, Ogawa Y and Sorrentino V: Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development. Cell Calcium 41: 573-580, 2007 [PubMed]
Morishima-Kawashima M, Han X, Tanimura Y, Hamanaka H, Kobayashi M, Sakurai T, Yokoyama M, Wada K, Nukina N, Fujita SC and Ihara Y: Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains. J Neurochem 101: 949-958, 2007 [PubMed]
Kudoh T, Murayama T, Matsuda A and Shuto S: Substitution at the 8-position of 3''-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca²⁺-mobilizing agent, provides partial agonists. Bioorg Med Chem 15: 3032-3040, 2007 [PubMed]
Murayama T, Oba T, Hara H, Wakebe K, Ikemoto N and Ogawa Y: Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia. Biochem J 402: 349-357, 2007 [PubMed]
Bannister ML, Hamada T, Murayama T, Harvey PJ, Casarotto MG, Dulhunty AF and Ikemoto N: Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area. Biochem J 401: 333-339, 2007 [PubMed]

総説・和文・招待講演

櫻井　隆：β切断の機能と調節機構. 実験医学増刊「脳神経疾患の分子病態と治療への展開」25 (13): 1923-1927, 2007

2006

原著論文

Kudoh T, Matsuda A, Shuto S, Murayama T and Ogawa Y: Synthesis of cyclic ADP-carbocylcic-xylose and its 3"-O-methyl analogue as stable and potent Ca²⁺-mobilizing agents. Nucleosides Nucleotides Nucleic Acids 25: 583-599, 2006 [PubMed]
Sakaguchi N, Kudoh T, Murayama T, Arisawa M, Matsuda A and Shuto S: Synthesis of 5''-substituted cyclic ADP-carbocyclic-ribose as biological tools. Nucleic Acids Symp Ser (Oxf): 119-120, 2006 [PubMed]

総説・和文・招待講演

Kurebayashi N. Regulation of intracellular Ca²⁺ by intercellular communication in cardiac muscle Muscle: Excitation-Contraction Coupling: Gordon Research Conference, 2006年6月.
櫻井　隆：ApoEとコレステロール・膜ラフト. 最新医学「アルツハイマー病研究の最前線」61: 2405-2410, 2006

2005

原著論文

Kubota M, Narita K, Murayama T, Suzuki S, Soga S, Usukura J, Ogawa Y and Kuba K: Type-3 ryanodine receptor involved in Ca²⁺-induced Ca²⁺ release and transmitter exocytosis at frog motor nerve terminals. Cell Calcium 38: 557-567, 2005 [PubMed]
Murayama T, Oba T, Kobayashi S, Ikemoto N and Ogawa Y: Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca²⁺-induced Ca²⁺ release activity of mammalian skeletal muscle sarcoplasmic reticulum. Am J Physiol Cell Physiol 288: C1222-C1230, 2005 [PubMed]
Kudoh T, Fukuoka M, Ichikawa S, Murayama T, Ogawa Y, Hashii M, Higashida H, Kunerth S, Weber K, Guse AH, Potter BV, Matsuda A and Shuto S: Synthesis of Stable and Cell-type Selective Analogues of Cyclic ADP-Ribose, a Ca²⁺-Mobilizing Second Messenger. Structure-Activity Relationship of the N1-Ribose Moiety(1). J Am Chem Soc 127: 8846-8855, 2005 [PubMed]
Kudoh T, Murayama T, Matsuda A and Shuto S: Synthesis and biological activity of 4'',6''-unsaturated cyclic ADP-carbocyclic-ribose. Nucleic Acids Symp Ser (Oxf): 25-26, 2005 [PubMed]

総説・和文・招待講演

Y. Ogawa, T. Murayama, N. Kurebayashi (2005) Functions of RyR3 homologues.
In : Ryanodine Receptors : Structure, Function and Dysfunction in Clinical Disease, (X. H. T. Wehrens., A. R. Marks., Eds.), pp131-140, Springer, New York.

2004

原著論文

Kurebayashi N, Yamashita H, Nakazato Y, Daida H and Ogawa Y: Behavior of Ca²⁺ waves in multicellular preparations from guinea pig ventricle. Am J Physiol Cell Physiol 287: C1646-1656, 2004 [PubMed]
Murayama T and Ogawa Y: RyR1 exhibits lower gain of CICR activity than RyR3 in the SR: evidence for selective stabilization of RyR1 channel. Am. J. Physiol. Cell Physiol. 287: C36-C45, 2004 [PubMed]

2003

原著論文

Kurebayashi N, Takeshima H, Nishi M, Murayama T, Suzuki E and Ogawa Y: Changes in Ca²⁺ handling in adult MG29-deficient skeletal muscle. Biochem. Biophys. Res. Commun. 310: 1266-1272, 2003 [PubMed]
Chugun A, Taniguchi K, Murayama T, Uchide T, Hara Y, Temma K, Ogawa Y and Akera T: Subcellular distribution of ryanodine receptors in the cardiac muscle of carp (Cyprinus carpio). Am. J. Physiol. Regul. Integr. Comp. Physiol. 285: R601-R609., 2003 [PubMed]

総説・和文・招待講演

Y. Ogawa, N. Kurebayashi, T. Murayama (2003) Ryanodine receptor.
in Encyclopedic Reference of Molecular Pharmacology, (S. Offermanns, W. Rosenthal Eds.), pp835-840, Springer-Verlag, Berlin & Heidelberg.
Y. Ogawa (2003) Pathways for Ca²⁺ entry in the striated muscles.
Gordon Resarch Conference on Muscle : Excitation-Contraction Coupling, New Hampshire, USA, June 8-13.

2002

原著論文

Xiao B, Masumiya H, Jiang D, Wang R, Sei Y, Zhang L, Murayama T, Ogawa Y, Lai FA, Wagenknecht T and Chen SR: Isoform-dependent formation of heteromeric Ca²⁺ release channels (ryanodine receptors). J Biol Chem 277: 41778-41785, 2002 [PubMed]
Oba T, Murayama T and Ogawa Y: Redox states of type 1 ryanodine receptor alter Ca²⁺ release channel response to modulators. Am J Physiol Cell Physiol 282: C684-C692, 2002 [PubMed]
Shiwa M, Murayama T and Ogawa Y: Molecular cloning and characterization of ryanodine receptor from unfertilized sea urchin eggs. Am J Physiol Regul Integr Comp Physiol 282: R727-737., 2002 [PubMed]

総説・和文・招待講演

Murayama T and Ogawa Y: Roles of two ryanodine receptor isoforms coexisting in skeletal muscle. Trends Cardiovasc Med 12: 305-311, 2002 [PubMed]
Ogawa Y, Murayama T and Kurebayashi N: Ryanodine receptor isoforms of non-mammalian skeletal muscle. Front Biosci 7: d1184-d1194, 2002 [PubMed]

2001

原著論文

Sato O and Ogawa Y: Myosin assembly critical for the enzyme activity of smooth muscle myosin phosphatase: effects of MgATP, ionic strength, and Mg(2+). J Biochem (Tokyo) 129: 881-889, 2001 [PubMed]
Kurebayashi N and Ogawa Y: Depletion of Ca²⁺ in the sarcoplasmic reticulum stimulates Ca²⁺ entry into mouse skeletal muscle fibres. J Physiol 533: 185-199, 2001 [PbuMed]
Yoshimura K, Takeuchi H, Sato O, Hidaka K, Doira N, Terunuma M, Harada K, Ogawa Y, Ito Y, Kanematsu T and Hirata M: Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1alpha. J Biol Chem 276: 17908-17913, 2001 [PubMed]
Murayama T and Ogawa Y: Selectively suppressed Ca²⁺-induced Ca²⁺ release activity of alpha-ryanodine receptor (alpha-RyR) in frog skeletal muscle sarcoplasmic reticulum: potential distinct modes in Ca²⁺ release between alpha- and beta-RyR. J Biol Chem 276: 2953-2960, 2001 [PubMed]

総説・和文・招待講演

村山　尚, 呉林なごみ, 小川靖男 (2001) 骨格筋筋小胞体のリアノジン受容体とカルシウム動態. 生体の科学, 52, 294-300.
呉林なごみ, 小川靖男 (2001) 骨格筋のカルシウム動態.Clinical Calcium, 1417-1423.

2000

原著論文

Oba T, Ishikawa T, Murayama T, Ogawa Y and Yamaguchi M: H2O2 and ethanol act synergistically to gate ryanodine receptor/calcium-release channel. Am. J. Physiol. (Cell Physiol.) 279: C1366-C1374, 2000 [PubMed]
Yamada A, Sato O, Watanabe M, Walsh MP, Ogawa Y and Imaizumi Y: Inhibition of smooth-muscle myosin-light-chain phosphatase by Ruthenium Red. Biochem J 349: 797-804, 2000 [PubMed]
Murayama T, Kurebayashi N and Ogawa Y: Role of Mg²⁺ in Ca²⁺-induced Ca²⁺ release through ryanodine receptors of frog skeletal muscle: Modulations by adenine nucleotides and caffeine. Biophys. J. 78: 1810-1824, 2000 [PubMed]

総説・和文・招待講演

Ogawa Y, Kurebayashi N and Murayama T: Putative roles of type 3 ryanodine receptor isoforms. Trends Cardiovasc Med 10: 65-70, 2000 [PubMed]
Y. Ogawa (2000) Different contributions between α-RyR and β-RyR to CICR activity in sarcoplasmic reticulum vesicles from frog skeletal muscles.
Gordon Research Conference on Muscle : Excitation-Contraction Coupling, New Hampshire, USA, June 11-16.