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‹¦—ÍŒ¤‹†ˆõ ˆäã —R—Žqiº˜a‘åŠwj
–ì’† ”üŠóiŽœŒbˆã‰È‘åŠwj
Šp“c ½i“Œ‹ž‘åŠwj
‰ß‹Ž‚ÌÝÐŽÒ V‰Æ —ړށi•‹³jA@•àV ‘åi‹¦—ÍŒ¤‹†ˆõjA@—é–Ø ®¶Žqi‘åŠw‰@¶jA@™Œ´ ‹§”üi‘åŠw‰@¶jA@¬“cØ Žj“¿i‘åŠw‰@¶jA@—é–Ø „i‘åŠw‰@¶jA@‰Ô“‡ Íi‹¦—ÍŒ¤‹†ˆõjA@‰F’à ”üHi‹¦—ÍŒ¤‹†ˆõjA@‹à _i‘åŠw‰@¶jAÎˆä Œõˆê˜Yi‘åŠw‰@¶j

ŸNˆä@—²
i‹³Žöj

Œo—ð

  • “Œ‹ž‘åŠwˆãŠw•”‘²‹Æ
  • “Œ‹ž‘åŠw‘åŠw‰@ˆãŠwŒnŒ¤‹†‰Èi–ò—ŠwjC—¹@ˆãŠw”ŽŽm

Œ¤‹†ƒe[ƒ}

  1. –Œƒ}ƒCƒNƒƒhƒƒCƒ“ˆË‘¶«ƒAƒ~ƒƒCƒh‘O‹ì‘Ì’`”’Ž¿‘ãŽÓ’²ß‹@\‚ÌŒ¤‹†
  2. Œõ‚ð—p‚¢‚½’`”’Ž¿‹@”\•sŠˆ‰»–@(CALI/FALI)‚É‚æ‚é‘n–ò•W“I‚Ì’Tõ

Žå‚ȋƐÑ>>Ú×

  1. Sakurai T, Kaneko K, Okuno M, et al. J Cell Biol, 183: 339-352, 2008
  2. Urushitani M, Sik A, Sakurai T, et al. Nature Neuroscience 9: 108-118, 2006
  3. Eustace BK, Sakurai T, Stewart JK et al. Nature Cell Biol 6: 507-514, 2004
  4. Sakurai T, et al. Proc Natl Acad Sci U S A 99:10795-10800, 2002

‘ºŽR@®
iy‹³Žöj

Žå‚ȋƐÑ>>Ú×

  1. Yamazawa T et al. Nat Commun, 12: 4293, 2021[Link]
  2. Mori S et al. Eur J Med Chem, 179: 837-848, 2019[Link]
  3. Murayama T et al. Mol Pharmacol, 94: 722-730, 2018[Link]
  4. Murayama T et al. Commun Biol, 1: 98, 2018[Link]

‘å‹v•Û@—m•½
iy‹³Žöj

Œo—ð

  • “Œ‹ž‘åŠw—Šw•”¶•¨‰»Šw‰È‘²‹Æ
  • “Œ‹ž‘åŠw‘åŠw‰@ˆãŠwŒnŒ¤‹†‰ÈC—¹
  • ˆãŠw”ŽŽm

Œ¤‹†ƒe[ƒ}

  1. ŒuŒõƒCƒ[ƒWƒ“ƒO‚É‚æ‚éƒVƒiƒvƒX“`’Bƒ_ƒCƒiƒ~ƒNƒX‚̉ðÍ

Žå‚ȋƐÑ>>Ú×

  1. Okubo Y et al. Glia, 67: 113-124, 2019[Link]
  2. Okubo Y et al. J Neurosci, 35: 15837-15846, 2015[Link]
  3. Okubo Y et al. Proc Nat Acad Sci USA, 107: 6526-6531, 2010[Link]
  4. Okubo Y et al. Neuron, 32: 113-122, 2001[Link]

ãŒE@—T“ñ
iy‹³Žöj

Œo—ð

  • ‘åã‘åŠw‘åŠw‰@¶–½‹@”\Œ¤‹†‰È@C—¹
  • ”ŽŽmi—Šwj

Œ¤‹†ƒe[ƒ}

  1. ƒƒ^ƒVƒiƒvƒX‰Â‘Y«‚̐¶—Šw“I‰ðÍ
  2. Žó—e‘Ì‘ŠŒÝì—p‚É‚æ‚é_Œo‹@”\‚̐§Œä

Žå‚ȋƐÑ>>Ú×

  1. Kamikubo Y et al. ACS Chem Neurosci.10: 304-312, 2019 [PubMed]
  2. Kamikubo Y et al. J Alzheimers Dis.;56:641-653, 2017 [PubMed]
  3. Kamikubo Y et al. J Neurosci, 33: 18661-18671, 2013 [PubMed]
  4. Kamikubo Y et al. J Physiol(Lond), 585: 549-563, 2007 [PubMed]

Œà—сi‘Lj@‚È‚²‚Ý
i‹qˆõy‹³Žöj

Žå‚ȋƐÑ>>Ú×

  1. Hirose et al., Europace, 2021; euab250[Link]
  2. Uehara et al., J Gen Physiol, 149: 199?218, 2017[Link]
  3. Odagiri et al., PLoS One; 9: e101838, 2014 [Link]

Š~ŽR@‘ñ
i•‹³j

Žå‚ȋƐÑ>>Ú×

  1. Kashiyama T, Murayama T et al. PLoS One 5: e11526, 2010 [PubMed]
  2. Sakurai T, Kashiyama T, Nukina N et al. J Cell Biol 183: 339-352, 2008 [PubMed]
  3. Ito K, Kashiyama T, Yamamoto K et al. J Biol Chem 282: 19534-19545,2007 [PubMed]
  4. Kashiyama T, Yamamoto K. J Mol Biol 311: 461-466,2001 [PubMed]

â“ü@”Œx
i•‹³j

Œo—ð

  • ‡“V“°‘åŠwˆãŠw•”‘²‹Æ
  • ‡“V“°‘åŠw‘åŠw‰@ˆãŠwŒ¤‹†‰È@”ŽŽm‰Û’ö@C—¹
  • ”ŽŽmiˆãŠwj

Œ¤‹†ƒe[ƒ}

  1. ˆÙŽíGPCRŠÔƒNƒƒXƒg[ƒN‚É‚æ‚é_Œo‹@”\’²ß‚ÆŽ¾Š³‚Æ‚ÌŠÖ˜A

Žå‚ȋƐÑ>>Ú×

  1. Sakairi H, Kamikubo Y et al. ACS Chem Neurosci. 11(4) 567-578, 2020 [PubMed]
  2. Kamikubo Y, Toshihide Tabata, Hakushun Sakairi et al. J Pharmacol Sci. 128(3) 125-30, 2015 [PubMed]

¬—с@‘ô–ç
i•‹³j

Œo—ð

  • –k—¢‘åŠw—Šw•”¶•¨‰ÈŠw‰È‘²‹Æ
  • “Œ‹ž‘åŠw‘åŠw‰@‘‡•¶‰»Œ¤‹†‰ÈC—¹
  • ”ŽŽmiŠwpj

Œ¤‹†ƒe[ƒ}

  1. œŠi‹Ø‚É‚¨‚¯‚é”÷¬ŠÇŒn‚Ì–ðŠ„‚ÉŠÖ‚·‚錤‹†
    • E—ÍŒv‘ª‚ƃCƒ[ƒWƒ“ƒO‚ð—p‚¢‚½œŠi‹Ø‚̐¶•¨•¨—
    • E‹ØÁ‚ɑ΂·‚é”÷¬ŠÇŒn‚̉ðÍ‚Æ‘n–ò‰ž—p
  2. ƒŠƒAƒmƒWƒ“Žó—e‘Ì‚Ì“®ì‹@\‚ÉŠÖ‚·‚錤‹†
    • EƒNƒ‰ƒCƒI“dŒ°‚É‚æ‚é\‘¢‰ðÍ‚ð—p‚¢‚½ƒCƒIƒ“ƒ`ƒƒƒlƒ‹‚̐¶•¨•¨—
    • E\‘¢E‹@”\‘ŠŠÖ‰ðÍ‚É‚æ‚é‘n–ò‰ž—p

Žå‚ȋƐÑ>>Ú×

  1. Kobayashi T et al. Nat Commun 13, 2821, 2022[Link]
  2. Yamazawa T, Kobayashi T et al. Nat Commun. 12(1):4293, 2021.[link]
  3. Kobayashi T et al. PLoS One. 12, e0183672, 2017.[link]
  4. Kobayashi T, Murayama T. PLoS One. 4, e7827, 2009.[link]

ŽR‰º@’¼–ç
iuŽtj

Œo—ð

  • ‰¡•lŽs—§‘åŠw‘åŠw‰@ˆãŠwŒ¤‹†‰È@C—¹
  • ˆãŠw”ŽŽm

Œ¤‹†ƒe[ƒ}

  1. _Œo×–E“à‚É‚¨‚¯‚鏬–E—A‘—‚ð‰î‚µ‚½×–E“àî•ñ“`”À‹@\

Žå‚ȋƐÑ>>Ú×

  1. Yamashita N, Joshi R, Zhang S, Zhang ZY, Kuruvilla R. Dev. Cell. 42, 626-639. 2017 [PubMed]
  2. Yamashita N, Kuruvilla R. Curr Opin Neurobiol. 39:139-45, 2016 [PubMed]
  3. Yamashita N, Yamane M, Suto F, Goshima Y. J Cell Sci. 129: 1802-1814, 2016 [PubMed]
  4. Yamashita N et al. Nat Commun. 5: 3424, 2014 [PubMed]

{‰ê@”ä“ÞŽq
i”ñí‹Î•‹³j

Œo—ð

  • “Œ‹ž‘åŠw—Šw•”‘²‹Æ
  • “Œ‹ž‘åŠw‘åŠw‰@—ŠwŒnŒ¤‹†‰ÈC—¹@”ŽŽmi—Šwj

Œ¤‹†ƒe[ƒ}

  1. Gƒ^ƒ“ƒpƒNŽ¿‹¤–ðŽó—e‘̂̃ŠƒKƒ“ƒh”FŽ¯‚¨‚æ‚уVƒOƒiƒ‹“`’B‹@\‚̉ðÍ

Žå‚ȋƐÑ>>Ú×

  1. Suga H, Ehlert FJ. Biochemistry 52: 4914-4928, 2013
  2. Ehlert FJ, Suga H, Griffin MT. J Pharmacol Exp Ther 338: 671-686, 2011
  3. Suga H, Sawyer GW, Ehlert FJ. Mol Pharmacol 78: 745-755, 2010
  4. Suga H, Ehlert FJ. Biochem Pharmacol 79: 1025-1035, 2010